We have collected the most exciting new researches in the field of genetics and cellular research in the past week.
Exosome therapeutics for non-small cell lung cancer tumorigenesis
Non-small cell lung cancer (NSCLC) remains an ongoing health concern, with poor treatment options and prognosis for many patients. Typically, individuals with lung cancer are detected at the middle and terminal stages, resulting in poor medical results due to lack of initial diagnosis and treatment. So, finding the initial specific and effective therapy options for lung cancer is necessary. In addition, exosomes are generally small lipid vesicles with a diameter in the nanometer range that are created and released by different cell types. Exosomes have therapeutic potential through delivering bioactive compounds including microRNAs, siRNAs, and therapeutic proteins to tumor cells, modifying the tumor microenvironment, and promoting anti-tumor immune responses. In recent years, exosome-based therapy has become known as an appropriate approach for NSCLC treatment. This review offers an overview of the possibility of exosome-based therapy for NSCLC, with an emphasis on mechanisms of action, preclinical research, and current clinical trials. Preclinical studies have shown that exosome-based therapy can decrease tumor growth, metastasis, and drug resistance in NSCLC models. Furthermore, ongoing clinical trials are looking at the safety and efficacy of exosome-based therapies in NSCLC patients, offering important insights into their translational prospects. Despite promising preclinical evidences, significant obstacles remain, including optimizing exosome isolation and purification techniques, standardizing production strategies, and developing scalable manufacturing processes. Overall, exosome-based therapy shows significant promise as a novel and various methods for treating NSCLC, with the potential to enhance patient outcomes and evolution cancer treatment.
The prospective roles of exosomes in pituitary tumors
Pituitary neuroendocrine tumors are common, typically benign intracranial neoplasms arising from well-differentiated anterior pituitary cells with prevalence of clinically relevant pituitary tumor of 89 in 100 000 people. Despite the growing number of published studies, there is still a need for diagnostic and predictive biomarkers of pituitary adenomas. Prompt determination of tendency of the tumor for invasive growth and aggressive behavior would allow for earlier and more effective treatment. Extracellular vesicles (EVs), including exosomes, are particles released by cells containing cell-specific cargo including a variety of bioactive molecules, such as DNA, messenger RNA, microRNA, long non-coding RNA, circular RNA, proteins, and lipids surrounded by lipid membranes, which act as mediators of cell to cell communication. The ability of exosomes to reflect the functional state of the tumor, transport informative molecules, and accessibility in body fluids make them promising candidates in the search for biomarkers and new therapeutic methods. This study aims to investigate the involvement of exosomes in the pathology of pituitary adenoma and their potential clinical applications.
Creative Biostructure Provides a Wide Range of Plant Exosomes to Enhance Skincare Research
Creative Biostructure, a leading provider of structural biology and membrane protein services, is excited to introduce its PNExo™ Exosome Series. This innovative line of plant-derived exosome products is specifically designed to support cutting-edge skincare research and formulation development.
Plant exosomes offer several unique benefits that make them an ideal component in skincare products. They integrate seamlessly with skin lipids, enhancing the diffusion and absorption of active ingredients. Plant exosomes are also excellent carriers for unstable and poorly permeable molecules like astaxanthin, retinol, and β-nicotinamide mononucleotide (NMN), improving their stability and skin permeability.
Naturally, plant exosomes possess anti-inflammatory, antioxidant, and anti-aging properties. They promote skin tissue healing and can mitigate the effects of environmental stressors. By harnessing the power of plants like broccoli, ginseng, strawberry, and aloe vera, researchers can create skincare formulations with enhanced efficacy and natural benefits.
Creative Biostructure‘s PNExo™ Exosome Series is produced using advanced ultracentrifugation and precipitation techniques, ensuring high purity and activity. These raw materials can be stored long-term as lyophilized products at 4°C or as frozen liquids at -20°C to -80°C, offering flexibility for researchers.